High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia

H Nückel, M Switala, CH Collins, L Sellmann… - Clinical …, 2009 - Elsevier
CD49d plays a critical role in leucocyte trafficking, activation and survival, and facilitates
interactions between leucocytes and stromal cells. Recent data give evidence for the …

CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential

TD Shanafelt, SM Geyer, ND Bone… - British journal of …, 2008 - Wiley Online Library
In vitro studies have demonstrated that surface expression of CD49d on chronic lymphocytic
leukaemia (CLL) B cells facilitates leukaemic cell–stromal interactions by binding to …

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia

V Gattei, P Bulian, MI Del Principe… - Blood, The Journal …, 2008 - ashpublications.org
CD49d/α4-integrin is variably expressed in chronic lymphocytic leukemia (CLL). We
evaluated its relevance as independent prognosticator for overall survival and time to …

CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression

E Tissino, F Pozzo, D Benedetti… - Blood, The Journal …, 2020 - ashpublications.org
CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The
cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL …

[HTML][HTML] The prognostic value of CD49d expression in Turkish patients with chronic lymphocytic leukemia

A Uzay, T Toptaş, I Kaygusuz, E Ekşioğlu-demiralp… - 2012 - jag.journalagent.com
OBJECTIVE: The aim of this study was to assess the prognostic value of CD49d expression
in Turkish chronic lymphocytic leukemia patients. METHODS: Data for 118 patients from a …

CD49d expression in chronic lymphocytic leukemia: a prognostic parameter and a therapeutic target

P Bulian, G Gaidano, GD Poeta, V Gattei - 2008 - Future Medicine
Evaluation of: Shanafelt TD, Geyer SM, Bone ND et al.: CD49d expression is an
independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a …

CD49d and CD26 are independent prognostic markers for disease progression in patients with chronic lymphocytic leukemia

L Ibrahem, WE Elderiny, L Elhelw, M Ismail - Blood Cells, Molecules, and …, 2015 - Elsevier
CLL is characterized by extremely variable clinical course. Several prognostic factors can
predict disease progression and therapeutic outcomes in those patients. The aim was to …

[HTML][HTML] CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia

D Rossi, A Zucchetto, FM Rossi, D Capello… - …, 2008 - haematologica.org
Identification of prognosticators for Binet A chronic lymphocytic leukemia is important for
selecting patients with dismal prognosis. We analyzed CD49d expression in 140 …

High levels of CD 20 expression predict good prognosis in chronic lymphocytic leukemia

C Fang, Y Zhuang, L Wang, L Fan, YJ Wu… - Cancer …, 2013 - Wiley Online Library
Heterogeneity of CD 20 expression exists in chronic lymphocytic leukemia (CLL), therefore,
we explored the prognostic significance of CD 20 expression in Chinese patients with CLL …

CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism

A Zucchetto, C Caldana, D Benedetti… - Blood, The Journal …, 2013 - ashpublications.org
CD49d is a negative prognosticator in chronic lymphocytic leukemia (CLL), expressed by∼
40% of CLL cases and associated with aggressive, accelerated clinical courses. In this …