Background The analgesic properties and mechanisms of loperamide hydrochloride, a
peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation …

The possible antihyperalgesic and antiallodynic activity of loperamide, an opioid agonist
which does not readily penetrate the blood–brain barrier, were examined in the spinal nerve …

Peripherally acting opioids are potentially attractive drugs for the clinical management of
certain chronic pain states due to the lack of centrally mediated adverse effects. However, it …

The antihyperalgesic properties of the opiate antidiarrheal agent loperamide (ADL 2-1294)
were investigated in a variety of inflammatory pain models in rodents. Loperamide exhibited …

Background Preclinical and clinical evidence indicates that locally administered opioid
agonists produce an antihyperalgesic effect through peripheral opioid receptors in inflamed …

Studies in experimental models and controlled patient trials indicate that opioids are
effective in managing neuropathic pain. However, side effects secondary to their central …

Loperamide reverses signs of mechanical hypersensitivity in an animal model of
neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the …

The intratibial inoculation of NCTC 2472 cells induces an osteosarcoma in C3H/HeJ mice.
These mice show thermal hyperalgesic responses which may be blocked by the local …

Morphine is a gold standard analgesic commonly used to alleviate pain. However, its use is
associated with unavoidable side effects including the risk for addiction. Peripherally …

The possible role of spinal prostanoids in the tactile allodynia and thermal hyperalgesia
associated with an experimental model of neuropathic pain was investigated. Neuropathic …