We recently described the occurrence of cryptorchidism, oligoasthenoteratozoospermia, and
genital abnormalities in patients with distal 15q chromosome structural abnormalities. This …

The insulin-like family of growth factors (IGFs)–composed of insulin, and insulin-like growth
factors I (IGF1) and II (IGF2)–provides essential signals for the control of testis development …

Testis size and sperm production are directly correlated to the total number of adult Sertoli
cells (SCs). Although the establishment of an adequate number of SCs is crucial for future …

Testicular development occurs prenatally in mammals. The developmental underlying
mechanism is only partially understood. The aim of the present investigation was to study …

Knockout of the gene encoding insulin‐like factor 3 (INSL3) results in cryptorchidism in mice
due to disruption of the transabdominal phase of testicular descent. This finding was …

Abstract Insulin-like factor 3 (INSL3) plays a crucial role in testicular descent. Genetic
ablation of Insl3 or its G protein-coupled receptor, leucine-rich repeat-containing G-protein …

The distribution and density of functional insulin-like growth factor I (IGF-I) receptors in
cryptorchid and scrotal rat testes and epididymides during gonadal development were …

Using specific monoclonal antibodies, the authors studied the distribution of insulin growth
factor-I (IGF-I) and its receptor in normal human testis by immunostaining techniques. IGF-I …

Objective To study the cellular patterns of gene expression for insulin-like growth factors I
and II (IGF-I and IGF-II), their receptors and specific high-affinity binding proteins (IGFBPs) in …

IGF-I regulates pituitaryand gonadal functions, and is pivotal for sexual development and
fertility in mammalian species. To better understand the function of autocrine IGF-I in Sertoli …