Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men

J Li, Y Li, KL Ivey, DD Wang, JE Wilkinson, A Franke… - Gut, 2022 - gut.bmj.com
Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link
between red meat intake and poor cardiometabolic health. We investigated whether gut …

[HTML][HTML] Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study/Study of …

Z Mei, GC Chen, Z Wang, M Usyk, B Yu… - The American journal of …, 2021 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO), a diet-derived and gut microbiota–
related metabolite, is associated with cardiovascular disease (CVD). However, major dietary …

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

S Rath, K Rox, S Kleine Bardenhorst, U Schminke… - …, 2021 - Am Soc Microbiol
The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an
increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently …

Trimethylamine‐N‐oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A …

CE Cho, S Taesuwan, OV Malysheva… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope Trimethylamine‐N‐oxide (TMAO), a metabolite linked to the gut microbiota, is
associated with excess risk of heart disease. We hypothesized that (i) TMAO response to …

[HTML][HTML] Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal …

BC Fu, MAJ Hullar, TW Randolph, AA Franke… - The American journal of …, 2020 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a compound derived from diet
and metabolism by the gut microbiome, has been associated with several chronic diseases …

Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers

JE Park, M Miller, J Rhyne, Z Wang… - Nutrition, Metabolism and …, 2019 - Elsevier
Background Dietary nutrient intake and its metabolism by the gut microbiome have recently
been implicated in cardiovascular disease (CVD) risk. In particular, trimethylamine N-oxide …

[HTML][HTML] Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis

JJ Yang, XO Shu, DM Herrington, SC Moore… - The American journal of …, 2021 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host
cometabolite, has been linked to cardiometabolic diseases. However, the relations remain …

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

Z Wang, N Bergeron, BS Levison, XS Li… - European heart …, 2019 - academic.oup.com
Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …

[HTML][HTML] Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

D Li, Y Lu, S Yuan, X Cai, Y He, J Chen, Q Wu… - The American journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

[HTML][HTML] Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

C Simó, V García-Cañas - Food & function, 2020 - pubs.rsc.org
There is a growing body of clinical evidence that supports a strong association between
elevated circulating trimethylamine N-oxide (TMAO) levels with increased risk of developing …