We explored the associations of aberrant DNA methylation patterns in 12 candidate genes
with adult glioma subtype, patient survival, and gene expression of enhancer of zeste …

Epigenetic changes play an important role in the pathogenesis of gliomas and have the
potential to become clinically useful biomarkers. The aim of this study was the evaluation of …

Gliomas are tumors of the central nervous system with a wide spectrum of different tumor
types. They range from pilocytic astrocytoma, with a generally good prognosis, to the …

Aberrant promoter hypermethylation of several known or putative tumor suppressor genes
occurs frequently during the malignant transformation in gliomas. We hypothesized that …

Objective: To identify a specific hypermethylated molecular biomarker for human malignant
glioblastoma prognosis. Materials and Methods: Genome-wide methylation profiling was …

Glioblastoma multiforme (GBM) is the most common, most invasive, and malignant type of
primary brain tumor with poor prognosis and poor survival rate. Using GSE22891 the …

This study aims to analyze expression of EZH2 and DNA-methyltransferases (DNMT1, 3A
and 3B) in astrocytic tumors and investigate their link as well as their correlation with …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Background Subtelomeric regions dynamically change their epigenetic pattern during
development and progression of several malignancies and degenerative disorders …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. The presence of epigenetic lesions, like hypermethylation of known tumor …