DNA methylation and gene expression
Z Siegfried, I Simon - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …
associated with a repressed chromatin state and inhibition of gene expression. The …
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
X Nan, HH Ng, CA Johnson, CD Laherty, BM Turner… - Nature, 1998 - nature.com
Cytosine residues in the sequence 5′ CpG (cytosine–guanine) are often postsynthetically
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
CpG content affects gene silencing in mice: evidence from novel transgenes
C Chevalier-Mariette, I Henry, L Montfort, S Capgras… - Genome biology, 2003 - Springer
Background Transgenes are often engineered using regulatory elements from distantly
related genomes. Although correct expression patterns are frequently achieved even in …
related genomes. Although correct expression patterns are frequently achieved even in …
Conserved role of intragenic DNA methylation in regulating alternative promoters
AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy …
GP Pfeifer, SD Steigerwald… - Proceedings of the …, 1990 - National Acad Sciences
The 5'region of the gene encoding human X chromosome-linked phosphoglycerate kinase 1
(PGK1) is a promoter-containing CpG island known to be methylated at 119 of 121 CpG …
(PGK1) is a promoter-containing CpG island known to be methylated at 119 of 121 CpG …
DNA methylation and chromatin structure: the puzzling CpG islands
P Caiafa, M Zampieri - Journal of cellular biochemistry, 2005 - Wiley Online Library
DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …
High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
F Antequera, J Boyes, A Bird - Cell, 1990 - cell.com
CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
JD Lewis, RR Meehan, WJ Henzel, I Maurer-Fogy… - Cell, 1992 - cell.com
Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …
chromatin structure. Recent evidence suggests that both effects are the result of an …
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and …
CT Nguyen, FA Gonzales, PA Jones - Nucleic acids research, 2001 - academic.oup.com
Silencing of tumor-suppressor genes by hypermethylation of promoter CpG islands is well
documented in human cancer and may be mediated by methyl-CpG-binding proteins, like …
documented in human cancer and may be mediated by methyl-CpG-binding proteins, like …