CpG methylation in vertebrates correlates with alterations in chromatin structure and gene
silencing 1, 2, 3, 4. Differences in DNA-methylation status are associated with imprinting …

Abnormalities of genomic methylation patterns are lethal or cause disease, but the cues that
normally designate CpG dinucleotides for methylation are poorly understood. We have …

Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …

In mammals and other vertebrates, cytosine methylation in CpG sites is often negatively
correlated with gene activity. Because methylation of the promoter region is most crucial for …

DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

De novo methylation of CpG islands within the promoters of eukaryotic genes is often
associated with their transcriptional repression, yet the methylation of CpG islands located …

Methylation of CpG-dinucleotides within proximal promoters is often associated with
transcriptional silencing. Methylation-dependent repression is well established for …

Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …

Studies of the whole genome by molecular and cytogenetic methods have implicated DNA
methylation in the formation of 'inactive chromatin'. This has been confirmed by analysis of …

DNA methylation plays an important role in the regulation of gene expression during
development. Methyl moieties at CpG residues suppress transcription by affecting DNA …