Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

This review summarizes the metabolism, secretion, regulation and sites of action of
melatonin. An updated description of the melatonin receptors, including their signal …

Melatonin is a fascinating molecule that has captured the imagination of many scientists
since its discovery in 1958. In recent times, the focus has changed from investigating its …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is a hormone produced mainly by the pineal gland in most vertebrate species,
including humans. Recent metabolic, receptor and functional studies created a picture of the …

Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted
during the night and appears to play multiple roles within the human organism. The …

Melatonin is a neurohormone synthesized in the pineal gland during the dark period in all
species, including humans. The diversity and differences in melatonin receptor distribution …

Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

The functional versatility and diversity of melatonin has exceeded everyone's expectations.
The evidence is substantial that melatonin has multiple receptor-mediated and receptor …