To investigate whether pan-schizophrenia genes could be leveraged for building cohort-
specific signatures reflecting the functioning of the affected brain, we first collected 1,518 …

Schizophrenia is a multifactorial disorder, the genetic architecture of which remains unclear.
Although many studies have examined the etiology of schizophrenia, the gene sets that …

Subtyping neuropsychiatric disorders like schizophrenia is essential for improving the
diagnosis and treatment of complex diseases. Subtyping schizophrenia is challenging …

Numerous studies have examined gene expression profiles in post-mortem human brain
samples from individuals with schizophrenia compared with healthy controls, to gain insight …

Abstract Analysis linking directly genomics, neuroimaging phenotypes and clinical
measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we …

Despite large-scale genome-wide association studies (GWAS), the underlying genes for
schizophrenia are largely unknown. Additional approaches are therefore required to identify …

It is widely accepted, given the complex nature of schizophrenia (SCZ) gene networks, that a
few or a small number of genes are unlikely to represent the underlying functional pathways …

Background Schizophrenia is a highly heritable brain disorder with a typical symptom onset
in early adulthood. The two-hit hypothesis posits that schizophrenia results from deviant …

Schizophrenia polygenic risk is plausibly manifested by complex transcriptional
dysregulation in the brain, involving networks of co-expressed and functionally related …

Schizophrenia is a highly heritable brain disorder with a typical symptom onset in early
adulthood. The two-hit hypothesis posits that schizophrenia results from deviant early …