Non-CG methylation in the human genome

Y He, JR Ecker - Annual review of genomics and human …, 2015 - annualreviews.org
DNA methylation is a chemical modification that occurs predominantly on CG dinucleotides
in mammalian genomes. However, recent studies have revealed that non-CG methylation …

CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression

R Chatterjee, C Vinson - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …

A unique role for DNA (hydroxy) methylation in epigenetic regulation of human inhibitory neurons

A Kozlenkov, J Li, P Apontes, YL Hurd, WM Byne… - Science …, 2018 - science.org
Brain function depends on interaction of diverse cell types whose gene expression and
identity are defined, in part, by epigenetic mechanisms. Neuronal DNA contains two major …

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites

A Kozlenkov, P Roussos, A Timashpolsky… - Nucleic acids …, 2014 - academic.oup.com
Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …

Mammalian non-CpG methylation: stem cells and beyond

SE Pinney - Biology, 2014 - mdpi.com
Although CpG dinucleotides remain the primary site for DNA methylation in mammals, there
is emerging evidence that DNA methylation at non-CpG sites (CpA, CpT and CpC) is not …

[HTML][HTML] Formation of methylation patterns in the mammalian genome

MS Turker, TH Bestor - Mutation Research/Reviews in Mutation Research, 1997 - Elsevier
Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

DNA methylation and human disease

KD Robertson - Nature Reviews Genetics, 2005 - nature.com
DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

CpG and non-CpG methylation in epigenetic gene regulation and brain function

HS Jang, WJ Shin, JE Lee, JT Do - Genes, 2017 - mdpi.com
DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

[HTML][HTML] DNA methylation signatures within the human brain

C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
DNA methylation is a heritable modification of genomic DNA central to development,
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …

Global epigenomic reconfiguration during mammalian brain development

R Lister, EA Mukamel, JR Nery, M Urich, CA Puddifoot… - Science, 2013 - science.org
Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …