Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

A change in chromosome number that is not the exact multiple of the haploid karyotype is
known as aneuploidy. This condition interferes with growth and development of an organism …

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date,
aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been
implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and …

Despite over 100 years of study, the role of aneuploidy in cancer remains poorly understood.
This review highlights the advances in understanding the causes and consequences of …

Accurate chromosome segregation during cell division is essential for genome integrity.
Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where …

Aneuploidy is frequently associated with disease and developmental abnormalities. It is also
a key characteristic of cancer. Several model systems have been developed to study the role …

Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant
cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of …