[HTML][HTML] Aberrant sperm DNA methylation predicts male fertility status and embryo quality

KI Aston, PJ Uren, TG Jenkins, A Horsager, BR Cairns… - Fertility and sterility, 2015 - Elsevier
Objective To evaluate whether male fertility status and/or embryo quality during in vitro
fertilization (IVF) therapy can be predicted based on genomewide sperm deoxyribonucleic …

[HTML][HTML] Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis

KI Aston, V Punj, L Liu, DT Carrell - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To evaluate genome-wide DNA methylation patterns in sperm from men with
abnormal sperm chromatin packaging and patients displaying abnormal embryogenesis …

[HTML][HTML] Decreased fecundity and sperm DNA methylation patterns

TG Jenkins, KI Aston, TD Meyer, JM Hotaling… - Fertility and sterility, 2016 - Elsevier
Objective To evaluate the relationship between epigenetic patterns in sperm and fecundity.
Design Prospective study. Setting Academic andrology and in vitro fertilization laboratory …

Sperm global DNA methylation level: association with semen parameters and genome integrity

D Montjean, A Zini, C Ravel, S Belloc, A Dalleac… - …, 2015 - Wiley Online Library
Sperm DNA methylation abnormalities have been detected in oligozoospermic men.
However, the association between sperm DNA methylation defects, sperm parameters and …

DNA methylation in human sperm: a systematic review

F Åsenius, AF Danson, SJ Marzi - Human reproduction update, 2020 - academic.oup.com
BACKGROUND Studies in non-human mammals suggest that environmental factors can
influence spermatozoal DNA methylation, and some research suggests that spermatozoal …

Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis

C Camprubí, A Salas-Huetos, R Aiese-Cigliano… - Reproductive …, 2016 - Elsevier
The influence of aberrant sperm DNA methylation on the reproductive capacity of couples
has been postulated as a cause of infertility. This study compared the DNA methylation of …

Impairment of sperm DNA methylation in male infertility: a meta‐analytic study

D Santi, S De Vincentis, E Magnani, G Spaggiari - Andrology, 2017 - Wiley Online Library
Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …

Genome-wide differential methylation analyses identifies methylation signatures of male infertility

KM Sujit, S Sarkar, V Singh, R Pandey… - Human …, 2018 - academic.oup.com
STUDY QUESTION Do methylation changes in sperm DNA correlate with infertility? STUDY
ANSWER Loss of spermatogenesis and fertility was correlated with 1680 differentially …

Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility

RG Urdinguio, GF Bayon, M Dmitrijeva… - Human …, 2015 - academic.oup.com
Abstract STUDY QUESTION Are there DNA methylation alterations in sperm that could
explain the reduced biological fertility of male partners from couples with unexplained …

Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures

TG Jenkins, KI Aston, JM Hotaling, MB Shamsi… - …, 2016 - Wiley Online Library
Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite
its relatively low predictive power. In this study, we have assessed associations between …