The downregulation of specific genes through DNA hypermethylation is a major hallmark of
cancer, although the extent and genomic distribution of hypermethylation occurring within …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Aberrant DNA methylation (DNAm) was first linked to cancer over 25 yr ago. Since then,
many studies have associated hypermethylation of tumor suppressor genes and …

Neuroblastoma (NB) pathogenesis has been reported to be closely associated with
numerous genetic alterations. However, underlying DNA methylation patterns have not been …

Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological
impact. Materials & methods: Microarray DNA methylation data were analyzed and …

CpG island hypermethylation has been recognized as an alternative mechanism for tumor
suppressor gene inactivation. In this study, we performed methylation-specific PCR (MSP) to …

Background Accurate outcome prediction in neuroblastoma, which is necessary to enable
the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. The presence of epigenetic lesions, like hypermethylation of known tumor …

Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM).
Our goals were to study differential methylation across the genome in gene promoters using …

Glioblastoma multiforme (GBM) is one of the most lethal and damaging types of human
cancer. The current study was conducted to identify differentially methylated genes (DMGs) …