Maintenance of DNA methylation: Dnmt3b joins the dance
EL Walton, C Francastel, G Velasco - Epigenetics, 2011 - Taylor & Francis
DNA methylation mostly occurs within the context of CpG dinucleotides and is essential for
embryonic development and gene repression. It is generally accepted that DNA …
embryonic development and gene repression. It is generally accepted that DNA …
DNMT3B functions: novel insights from human disease
M Gagliardi, M Strazzullo… - Frontiers in cell and …, 2018 - frontiersin.org
DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …
structure. Its proper establishment and maintenance are essential for mammalian …
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells
DJ Weisenberger, M Velicescu, MA Preciado-Lopez… - Gene, 2002 - Elsevier
CpG methylation is mediated by the functions of at least three active DNA
methyltransferases (DNMTs). While DNMT1 is thought to perform maintenance methylation …
methyltransferases (DNMTs). While DNMT1 is thought to perform maintenance methylation …
Cell and molecular biology of DNA methyltransferase 1
KN Mohan, JR Chaillet - International review of cell and molecular biology, 2013 - Elsevier
The DNA cytosine methyltransferase 1 (DNMT1) is a ubiquitous nuclear enzyme that
catalyzes the well-established reaction of placing methyl groups on the unmethylated …
catalyzes the well-established reaction of placing methyl groups on the unmethylated …
Non-catalytic functions of DNMT1
J Espada - Epigenetics, 2012 - Taylor & Francis
Mammalian DNA methyltransferase 1 (DNMT1) is essential during early embryo
development. Consistent with its key role in embryogenesis, depletion of this protein in adult …
development. Consistent with its key role in embryogenesis, depletion of this protein in adult …
Role of mammalian DNA methyltransferases in development
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles in
developmental and cellular processes. Their enzymatic activities are stimulated by a …
developmental and cellular processes. Their enzymatic activities are stimulated by a …
DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
N Veland, Y Lu, S Hardikar, S Gaddis… - Nucleic acids …, 2019 - academic.oup.com
Abstract DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA
methyltransferase activity but regulates de novo DNA methylation. While biochemical …
methyltransferase activity but regulates de novo DNA methylation. While biochemical …
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …