Methylation of promoter regions of CpG-rich sites is an important mechanism for silencing of
tumor suppressor genes (TSG). To evaluate the role of tumor suppressor genes caspase-8 …

Aberrant methylation of promoter CpG islands in human genes is an alternative genetic
inactivation mechanism that contributes to the development of human tumors. Nevertheless …

Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous
regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation …

Aberrant methylation of promoter CpG islands in human genes represents an alternative
mechanism for genetic inactivation, and contributes to the development of human tumors …

CpG island hypermethylation has been recognized as an alternative mechanism for tumor
suppressor gene inactivation. In this study, we performed methylation-specific PCR (MSP) to …

Aberrant methylation of CpG islands located in promoter regions represents one of the major
mechanisms for silencing of cancer-related genes in tumour cells. We determined the …

Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the
significance of epigenetic rather than genetic lesions in medulloblastomas and other …

Methylation of the promoter regions of CpG-rich sites in genes is the major mechanism for
the silencing of many genes in tumors. Methylation of the key apoptosis-related gene …

CpG‐island hypermethylation of gene promoters is a frequent mechanism for gene
inactivation in tumors. Many neuroblastomas have hypermethylation and down‐regulation of …

Promoter hypermethylation represents a primary mechanism in the inactivation of tumor
suppressor genes during tumorigenesis. To determine the frequency and timing of …