The prevalence of chronic kidney disease (CKD) and end-stage Kidney disease (ESKD) is
continuing to rise. Meticulous attention to drug dosing is paramount in patients with reduced …

This is the second editorial in this series examining new oncology therapeutics and
applications for which therapeutic drug monitoring (TDM)-adjusting dosages to improve …

Current guidance for evaluation of kidney function and drug dosing emphasize using
measured or estimated glomerular filtration rate (GFR) rather than measured or estimated …

The population pharmacokinetics and pharmacodynamics of cisplatin (CDDP) were
evaluated based on a mixed‐effect model using the NONMEM program. Unchanged CDDP …

Background Clinicians frequently require an estimate of renal function when determining the
dosage of drugs with a narrow therapeutic index, in particular, cytotoxic chemotherapeutic …

Many narrow therapeutic index drugs are eliminated primarily by hepatic metabolism.
Selecting the proper dosing regimen for such drugs in the presence of liver disease is an …

2601 Background: For many drugs, impaired renal function (RF) may alter pharmacokinetics
(PK) to an extent requiring dosage adjustment. The CG is commonly utilized in approved …

Introduction Chronic kidney disease is a common, progressive illness that is becoming a
global public health problem. In patients with kidney dysfunction, the renal excretion of …

Variability in individual therapeutic response to medication has long been recognized.
These patient-specific phenomena, characterized as “idiosyncrasy or constitutional …

Chronic kidney disease is a common occurrence in patients with gynecological cancer.
Systemic anticancer treatment in such patients is a challenge for clinicians because of …