The attrition rate in drug development is being reduced by continuous advances in science
and technology introduced by various academic institutions and pharmaceutical companies …

Purpose: The purpose of this study was to identify patient characteristics that may be risk
factors or markers of susceptibility to adverse treatment effects in cancer Phase I and II …

The doses of anticancer drugs are usually calculated according to the body surface area.
This practice is based on the hypothesis that clearance is proportional to this morphologic …

Clinical pharmacology is the branch of pharmacology that focuses on the study of drugs in
humans. A comprehensive understanding of the principles of clinical pharmacology …

Renal (RIP) and hepatic (HIP) impairments are prevalent conditions in cancer patients. They
can cause changes in gastric emptying time, albumin levels, hematocrit, glomerular filtration …

High drug attrition rates remain a critical issue in oncology drug development. A series of
steps during drug development must be addressed to better understand the …

Together with drug excretion, drug metabolism is an important mechanism of drug
elimination from the human body. This is achieved by biotransformation of (lipophilic) drug …

OBJECTIVE: To critically review available data on the disposition of cancer chemotherapy in
patients with hepatic dysfunction, and to derive at dose recommendation. DATA SOURCES …