Regulation of Active DNA Demethylation by a Methyl-CpG-Binding Domain Protein in Arabidopsis thaliana

Q Li, X Wang, H Sun, J Zeng, Z Cao, Y Li, W Qian - PLoS Genetics, 2015 - journals.plos.org
Active DNA demethylation plays crucial roles in the regulation of gene expression in both
plants and animals. In Arabidopsis thaliana, active DNA demethylation is initiated by the …

The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing

Z Lang, M Lei, X Wang, K Tang, D Miki, H Zhang… - Molecular cell, 2015 - cell.com
DNA methylation is a conserved epigenetic mark that plays important roles in plant and
vertebrate development, genome stability, and gene regulation. Canonical Methyl-CpG …

Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis

W Qian, D Miki, M Lei, X Zhu, H Zhang, Y Liu, Y Li… - Molecular cell, 2014 - cell.com
DNA methylation patterns are dynamically controlled by DNA methylation and active DNA
demethylation, but the mechanisms of regulation of active DNA demethylation are not well …

Characterization of Arabidopsis thaliana methyl‐CpG‐binding domain (MBD) proteins

A Zemach, G Grafi - The Plant Journal, 2003 - Wiley Online Library
Cytosine methylation at symmetrical CpG and CpNpG sequences plays a key role in the
epigenetic control of plant growth and development; yet, the way by which the methylation …

A novel protein complex that regulates active DNA demethylation in Arabidopsis

P Liu, WF Nie, X Xiong, Y Wang, Y Jiang… - Journal of Integrative …, 2021 - Wiley Online Library
Active DNA demethylation is critical for altering DNA methylation patterns and regulating
gene expression. The 5‐methylcytosine DNA glycosylase/lyase ROS1 initiates a base …

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

D Li, AMS Palanca, SY Won, L Gao, Y Feng… - Elife, 2017 - elifesciences.org
DNA methylation is associated with gene silencing in eukaryotic organisms. Although
pathways controlling the establishment, maintenance and removal of DNA methylation are …

Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis

C Wang, X Dong, D Jin, Y Zhao, S Xie, X Li… - Plant …, 2015 - academic.oup.com
Although researchers have established that DNA methylation and active demethylation are
dynamically regulated in plant cells, the molecular mechanism for the regulation of active …

Dual control of ROS1‐mediated active DNA demethylation by DNA damage‐binding protein 2 (DDB2)

D Córdoba‐Cañero, V Cognat, RR Ariza… - The Plant …, 2017 - Wiley Online Library
By controlling gene expression, DNA methylation contributes to key regulatory processes
during plant development. Genomic methylation patterns are dynamic and must be properly …

Genetic interactions between DNA demethylation and methylation in Arabidopsis

J Penterman, R Uzawa, RL Fischer - Plant Physiology, 2007 - academic.oup.com
DNA demethylation in Arabidopsis (Arabidopsis thaliana) is mediated by DNA glycosylases
of the DEMETER family. Three DEMETER-LIKE (DML) proteins, REPRESSOR OF …

A DNA 3′ phosphatase functions in active DNA demethylation in Arabidopsis

MI Martínez-Macías, W Qian, D Miki, O Pontes, Y Liu… - Molecular cell, 2012 - cell.com
DNA methylation is an important epigenetic mark established by the combined actions of
methylation and demethylation reactions. Plants use a base excision repair pathway for …