OBJECTIVE: To evaluate the associations between proper protamine incorporation and
DNA methylation at imprinted loci. DESIGN: Experimental research study. SETTING …

Background Male infertility is a complex disease caused by a combination of genetic,
environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed …

Male factor infertility has been associated with abnormal DNA methylation at imprinted
genes. Little information is available on the status of imprinting in the sperm of men with …

Recent studies suggest that assisted reproductive technologies (ART), which involve the
isolation, handling and culture of gametes and early embryos, are associated with an …

Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …

The role of epigenetic modifications in oligozoospermia and other disorders of
spermatogenesis remains poorly understood. While a variety of environmental, nutritional …

Disorders in genetic imprinting are discussed as potential genetic risk in assisted
reproduction technology (ART), where most of the natural selection mechanisms are …

OBJECTIVE: To evaluate genome-wide DNA methylation patterns in sperm from men with
abnormal sperm chromatin packaging and patients displaying abnormal embryogenesis …

Genomic imprinting marks in the male germ line are already established in the adult
germinal stem cell population. We studied the methylation patterns of H19 and MEST …

STUDY QUESTION What is the sperm DNA methylation status of imprinted genes in male
partners from couples experiencing recurrent pregnancy loss (RPL)? SUMMARY ANSWER …