Background: We sought to compare the efficacy of midazolam versus dexmedetomidine for
sedation during mechanical ventilation in infants and children. Methods: We performed a …

Intravenous midazolam has been widely used in paediatric patients for conscious sedation
in procedures such as endoscopy, oesophageal manometry, biopsy, bone marrow …

Aims Inflammation and organ failure have been reported to have an impact on cytochrome
P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to …

A simple, selective high‐performance liquid chromatographic method with ultraviolet
detection at 220nm is described for quantitation of midazolam and its primary metabolite 1 …

Conclusions The pharmacokinetics of midazolam in our patients showed a shorter half-life,
probably due to the higher hepatic clearance based on the high CI in children, as …

Midazolam, a short-acting benzodiazepine, is widely used to alleviate patient anxiety,
enhance compliance, and aid in anesthesia. While its side effects are typically dose …

Pediatric Critical Care Medicine www. pccmjournal. org 183 a validated sedation
assessment tool in combination with an algorithm that clearly delineates the necessary …

Background: Physiological‐based pharmacokinetic models have been used to describe
midazolam clearance (CL) maturation. There are no maturation descriptors of CL from …

Objective: This study was performed to determine the doses of midazolam used for sedation
during procedures in children, and the frequency of adverse events. Methods: We performed …

Aims: To identify PICU management practices of sedation, and their relationship with
relevant clinical outcomes. Methods: We conducted a multicentre, prospective longitudinal …