Background Children in paediatric intensive care units (PICUs) require analgesia and
sedation but both undersedation and oversedation can be harmful. Objective Evaluation of …

Whether age and sex influence the depth of sedation and the pharmacokinetics of
midazolam is currently unknown. The influence of age and sex was investigated in 117 …

Background Preanesthetic medication is important to eliminate surgical anxiety in pediatric
patients and facilitate their smooth transfer to the operating room. Midazolam is the most …

Sedation is currently administered to neonates experiencing pain and stress during
intensive care for medical diseases, as well as postoperatively. Drugs commonly used for …

Background Oral midazolam is widely used for preoperative sedation in children. We have
studied the pharmacokinetics (PK) of both midazolam and its active l-hydroxy metabolite and …

Aims No drug has been demonstrated to provide simultaneously appropriate sedation,
safety and lack of disturbance of the measured parameters during cardiac catheterization in …

Purpose The aim of the present study was to develop a population pharmacokinetic model
of midazolam, and to evaluate the influence of maturation process and other variability …

Ozalin®, a novel oral solution of 0.2% midazolam, is an effective option for moderate
sedation prior to a therapeutic or diagnostic procedure, and as premedication before …

Background Because information on the optimal dose of midazolam for sedation of
nonventilated infants after major surgery is scant, a population pharmacokinetic and …

Advances in critical care for infants and children, the increasing complexity and severity of
illnesses in children now surviving, and the introduction of new therapeutic drugs have led to …