Introduction: Until date, the methods employed in the quantification of midazolam during
sedation and in pre-anesthetic patients are somewhat complex and costly. Hence, the …

Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …

Midazolam (MDZ) is used for sedation in surgical procedures; its clinical effect is related to
its receptor affinity and the dose administered. Therefore, a pharmacokinetic …

Background: Sedation in children remains a controversial issue in emergency departments
(ED). Midazolam, as a benzodiazepine is widely used for procedural sedation among …

Background: We undertook a study to determine the effects of four routes of administation on
the efficacy of midazolam for premedication. Methods: In a randomized double‐blind study …

Background Although the pharmacokinetics of midazolam in critically ill children has been
described, there are no such reports in extracorporeal membrane oxygenation. Methods The …

1. Background Neonatal respiratory distress syndrome (NRDS), also known as hyaline
membrane disease (HMD), is a lifethreatening pulmonary disorder and a medical …

Midazolam and fentanyl infusions are commonly used for prolonged sedation and analgesia
in the pediatric intensive care setting. Tolerance and withdrawal are major concerns when …

Purpose In preterm infants, the biotransformation of midazolam (M) to 1-OH-midazolam
(OHM) by cytochrome P450 3A4 (CYP3A4) is developmentally immature, but it is currently …

Objective: Children admitted to pediatric intensive care units (PICUs) often receive sedatives
to facilitate mechanical ventilation. However, despite their widespread use, data supporting …