Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …

Histones are the major protein constituent of chromatin in the eukaryotic nucleus. These
proteins undergo a host of different post-translational modifications, including …

Methylation marks on the lysine residues of histone proteins are thought to contribute to
epigenetic phenomena in part because of their apparent irreversibility. Will this view change …

The specific post-translational modifications of the histone proteins are associated with
specific DNA-templated processes, such as transcriptional activation or repression. To …

Lysine methylation is an important post-translational modification of histone proteins that
defines epigenetic status and controls heterochromatin formation, X-chromosome …

Histone lysine residues can be mono-, di-, or trimethylated. These posttranslational
modifications regulate the affinity of effector proteins and may also impact chromatin …

Lysine histone methylation is one of the most robust epigenetic marks and is essential for
the regulation of multiple cellular processes. The methylation of Lys4 of histone H3 seems to …

Methylation of histone lysine residues in eukaryotic chromatin has been an exciting area of
research ever since the first histone methyltransferase enzyme, Suv39h, was found to …

Methylation of histones modulates chromatin structure and function. Whereas methylation of
histone H3 on lysines 4, 36, and 79 has been linked with gene activation, methylation of H3 …

Epigenetic gene silencing in eukaryotes is regulated in part by lysine methylation of the core
histone proteins. While histone lysine methylation is known to control gene expression …