Lysine residues within histones can be mono-, di-or tri-methylated. In Saccharomyces
cerevisiae tri-methylation of Lys 4 of histone H3 (K4/H3) correlates with transcriptional …

Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification
whose role in the regulation of gene expression has been extensively studied. In contrast …

Lysine methylation mediated by methyltransferase enzymes is present on multiple proteins
throughout the cell; however, methods to uncover and characterize global protein lysine …

Heterochromatin assembly requires methylation of histone H3 lysine 9 (H3K9me) and
serves as a paradigm for understanding the importance of histone modifications in …

Histone methylation plays a fundamental role in the epigenetic regulation of gene
expression driven by developmental and environmental cues in plants, including …

Epigenetic information refers to heritable changes in gene function that are stable between
cell divisions but which is not a result of changes in the DNA sequence. Part of the …

Maintenance of genomic integrity is essential to ensure normal organismal development
and to prevent diseases such as cancer. Nuclear DNA is packaged into chromatin, and thus …

In the last few years, the discovery of lysine and arginine methylation in histones and other
proteins and the enzymes that carry out these posttranslational modifications has added a …

Cells employ elaborate mechanisms to introduce structural and chemical variation into
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …

Figure 1. Genome versus epigenomes. The figure illustrates the distinction between genome
(DNA sequence) and epigenome (the collective modification pattern of chromatin). Various …