Post-translational modification of chromatin has profound effects on many biological
processes including transcriptional regulation, heterochromatin organization, and X …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …

Recent findings suggest that lysine and arginine-specific methylation of histones may
cooperate with other types of post-translational histone modification to regulate chromatin …

The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is …

Post-synthetic modification of histone proteins in chromatin architecture plays a central role
in the epigenetic regulation of transcription. Histone acetylation and methylation are the two …

DNA methylation is important in the control of gene transcription and chromatin structure.
The complexities of this process are just beginning to be elucidated in relationship to other …

Methylation of specific histone residues is capable of both gene activation and silencing.
Despite vast work on the function of methylation, most studies either present a static …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Abstract Histone H3 lysine 9 (H3-K9) methylation has been shown to correlate with
transcriptional repression and serve as a specific binding site for heterochromatin protein 1 …

Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …