DNA methylation status predicts cell type‐specific enhancer activity
M Wiench, S John, S Baek, TA Johnson… - The EMBO …, 2011 - embopress.org
Cell‐selective glucocorticoid receptor (GR) binding to distal regulatory elements is
associated with cell type‐specific regions of locally accessible chromatin. These regions can …
associated with cell type‐specific regions of locally accessible chromatin. These regions can …
Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation
The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated
transcription factor, show little overlap between cell types. To study the role of chromatin and …
transcription factor, show little overlap between cell types. To study the role of chromatin and …
Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo
TA Johnson, RV Chereji, DA Stavreva… - Nucleic Acids …, 2018 - academic.oup.com
Glucocorticoid hormone plays a major role in metabolism and disease. The hormone-bound
glucocorticoid receptor (GR) binds to a specific set of enhancers in different cell types …
glucocorticoid receptor (GR) binds to a specific set of enhancers in different cell types …
[HTML][HTML] Glucocorticoid receptor binding induces rapid and prolonged large-scale chromatin decompaction at multiple target loci
Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific
motifs within enhancers of target genes to activate transcription. Previous studies have …
motifs within enhancers of target genes to activate transcription. Previous studies have …
Chromatin architecture defines the glucocorticoid response
The glucocorticoid receptor (GR) functions to regulate a wide group of physiological
processes through hormone inducible interaction with genomic loci and subsequent …
processes through hormone inducible interaction with genomic loci and subsequent …
Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element
KS Zaret, KR Yamamoto - Cell, 1984 - cell.com
A derivative of mouse mammary tumor virus (MTV) DNA, LTL, was constructed in vitro and
introduced into the genome of mouse L cells. Transcription of LTL was stimulated by …
introduced into the genome of mouse L cells. Transcription of LTL was stimulated by …
Glucocorticoid receptor-mediated chromatin remodeling in vivo
BJ Deroo, TK Archer - Oncogene, 2001 - nature.com
The compaction of DNA into chromatin provides an additional level of gene regulation in
eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most …
eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most …
Epigenetic mechanisms of the glucocorticoid receptor
The glucocorticoid receptor (GR) has been shown to be important for mediating cellular
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
[HTML][HTML] Pre-established chromatin interactions mediate the genomic response to glucocorticoids
The glucocorticoid receptor (GR) is a hormone-inducible transcription factor involved in
metabolic and anti-inflammatory gene expression responses. To investigate what controls …
metabolic and anti-inflammatory gene expression responses. To investigate what controls …
DNA methylation‐mediated epigenetic control
A Rottach, H Leonhardt, F Spada - Journal of cellular …, 2009 - Wiley Online Library
During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …
changes without any change in the DNA sequence. The underlying changes of gene …
相关搜索
- dna methylation status
- cell type enhancer activity
- cell type glucocorticoid receptor
- cell type gene regulation
- local effect dna methylation
- epigenetic control dna methylation
- histone acetylation dna methylation
- cell type chromatin landscape
- glucocorticoid receptor gene regulation
- glucocorticoid receptor chromatin decompaction
- glucocorticoid receptor epigenetic mechanisms
- chromatin landscape gene regulation
- glucocorticoid receptor target loci
- glucocorticoid receptor chromatin landscape