DNA methylation status predicts cell type‐specific enhancer activity

M Wiench, S John, S Baek, TA Johnson… - The EMBO …, 2011 - embopress.org
Cell‐selective glucocorticoid receptor (GR) binding to distal regulatory elements is
associated with cell type‐specific regions of locally accessible chromatin. These regions can …

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

MI Love, MR Huska, M Jurk, R Schöpflin… - Nucleic acids …, 2017 - academic.oup.com
The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated
transcription factor, show little overlap between cell types. To study the role of chromatin and …

Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo

TA Johnson, RV Chereji, DA Stavreva… - Nucleic Acids …, 2018 - academic.oup.com
Glucocorticoid hormone plays a major role in metabolism and disease. The hormone-bound
glucocorticoid receptor (GR) binds to a specific set of enhancers in different cell types …

[HTML][HTML] Glucocorticoid receptor binding induces rapid and prolonged large-scale chromatin decompaction at multiple target loci

AW Jubb, S Boyle, DA Hume, WA Bickmore - Cell reports, 2017 - cell.com
Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific
motifs within enhancers of target genes to activate transcription. Previous studies have …

Chromatin architecture defines the glucocorticoid response

CJ Burd, TK Archer - Molecular and cellular endocrinology, 2013 - Elsevier
The glucocorticoid receptor (GR) functions to regulate a wide group of physiological
processes through hormone inducible interaction with genomic loci and subsequent …

Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element

KS Zaret, KR Yamamoto - Cell, 1984 - cell.com
A derivative of mouse mammary tumor virus (MTV) DNA, LTL, was constructed in vitro and
introduced into the genome of mouse L cells. Transcription of LTL was stimulated by …

Glucocorticoid receptor-mediated chromatin remodeling in vivo

BJ Deroo, TK Archer - Oncogene, 2001 - nature.com
The compaction of DNA into chromatin provides an additional level of gene regulation in
eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most …

Epigenetic mechanisms of the glucocorticoid receptor

AA Bartlett, HE Lapp, RG Hunter - Trends in Endocrinology & Metabolism, 2019 - cell.com
The glucocorticoid receptor (GR) has been shown to be important for mediating cellular
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …

[HTML][HTML] Pre-established chromatin interactions mediate the genomic response to glucocorticoids

AM D'Ippolito, IC McDowell, A Barrera, LK Hong… - Cell systems, 2018 - cell.com
The glucocorticoid receptor (GR) is a hormone-inducible transcription factor involved in
metabolic and anti-inflammatory gene expression responses. To investigate what controls …

DNA methylation‐mediated epigenetic control

A Rottach, H Leonhardt, F Spada - Journal of cellular …, 2009 - Wiley Online Library
During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …