Some of the key players of the methylation machinery are now in hand, offering an
opportunity to resolve contentious issues in the field of methylation. Perhaps the most …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …

Imprinted genes are epigenetically regulated so that only one allele is expressed in a parent-
of-origin-dependent manner. Although they represent a small subset of the mammalian …

DNA methylation is crucial for mammalian development because embryos that cannot
maintain normal methylation levels die after gastrulation. I propose that DNA methylation is …

DNA methylation plays essential roles in mammals. Of particular interest are parental
methylation marks that originate from the oocyte or the sperm, and bring about mono-allelic …

DNA methylation is an essential epigenetic mark crucial for normal mammalian
development. This modification controls the expression of a unique class of genes …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Imprinted genes have patterns of expression that depend on the parent of origin of their
alleles. Establishment of imprinting at a locus requires that the two alleles be differentially …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …