[HTML][HTML] Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono (2 …

JH Kamstra, LB Sales, P Aleström, J Legler - Epigenetics & chromatin, 2017 - Springer
Background Exposure to environmental stressors during development may lead to latent
and transgenerational adverse health effects. To understand the role of DNA methylation in …

[HTML][HTML] Translational toxicoepigenetic meta-analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead …

RL Petroff, DC Dolinoy, K Wang, L Montrose… - Environment …, 2024 - Elsevier
Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …

[HTML][HTML] Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice

RL Petroff, RG Cavalcante, JA Colacino… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: The developing epigenome changes rapidly, potentially making it more
sensitive to toxicant exposures. DNA modifications, including methylation and …

Role of DNA methylation in altered gene expression patterns in adult zebrafish (Danio rerio) exposed to 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126)

N Aluru, SI Karchner, KS Krick, W Zhu… - Environmental …, 2018 - academic.oup.com
There is growing evidence that environmental toxicants can affect various physiological
processes by altering DNA methylation patterns. However, very little is known about the …

Zebrafish as a model to study the role of DNA methylation in environmental toxicology

JH Kamstra, P Aleström, JM Kooter, J Legler - Environmental Science and …, 2015 - Springer
Environmental epigenetics is a rapidly growing field which studies the effects of
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …

Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo [a] pyrene exposure

J Corrales, X Fang, C Thornton, W Mei… - … and Physiology Part C …, 2014 - Elsevier
Abstract Benzo [a] pyrene (BaP) is an established carcinogen and reproductive and
developmental toxicant. BaP exposure in humans and animals has been linked to infertility …

Zebrafish embryos as a screen for DNA methylation modifications after compound exposure

MC Bouwmeester, S Ruiter, T Lommelaars… - Toxicology and applied …, 2016 - Elsevier
Modified epigenetic programming early in life is proposed to underlie the development of an
adverse adult phenotype, known as the Developmental Origins of Health and Disease …

Perinatal DEHP exposure induces sex-and tissue-specific DNA methylation changes in both juvenile and adult mice

S Liu, K Wang, LK Svoboda, CA Rygiel… - Environmental …, 2021 - academic.oup.com
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a type of phthalate plasticizer found in a
variety of consumer products and poses a public health concern due to its metabolic and …

Reproductive effects linked to DNA methylation in male zebrafish chronically exposed to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate

YB Ma, PP Jia, M Junaid, L Yang, CJ Lu, DS Pei - Environmental Pollution, 2018 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) possesses the potential to interfere with the
male reproductive endocrine system in mammals; however, its reproductive toxicity in male …

[HTML][HTML] Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver

Y Wen, S Rattan, JA Flaws, J Irudayaraj - Toxicology and applied …, 2020 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known
endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes …