Extracellular vesicles in glioblastoma tumor microenvironment

A Yekula, A Yekula, K Muralidharan, K Kang… - Frontiers in …, 2020 - frontiersin.org
Glioblastomas (GBM) are highly aggressive primary brain tumors. Complex and dynamic
tumor microenvironment (TME) plays a crucial role in the sustained growth, proliferation, and …

Breaking through the glioblastoma micro-environment via extracellular vesicles

T Simon, E Jackson, G Giamas - Oncogene, 2020 - nature.com
Glioblastoma (GBM) is the most common and most aggressive brain tumour. Prognosis
remains poor, despite the combined treatment of radio-and chemotherapy following surgical …

Extracellular vesicles in the glioblastoma microenvironment: a diagnostic and therapeutic perspective

MN Russo, LA Whaley, ES Norton, N Zarco… - Molecular aspects of …, 2023 - Elsevier
Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal
primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on …

Extracellular vesicles and their role in glioblastoma

CA Whitehead, AH Kaye, KJ Drummond… - Critical Reviews in …, 2020 - Taylor & Francis
Research on the role of extracellular vesicles (EVs) in disease pathogenesis has been
rapidly growing over the last two decades. As EVs can mediate intercellular communication …

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

S Oushy, JE Hellwinkel, M Wang… - … of the Royal …, 2018 - royalsocietypublishing.org
Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We
desperately need novel approaches to understand GBM biology and therapeutic …

Extracellular vesicles released by glioblastoma cells stimulate normal astrocytes to acquire a tumor-supportive phenotype via p53 and MYC signaling pathways

S Hallal, DM Mallawaaratchy, H Wei… - Molecular …, 2019 - Springer
The role of astrocytes is becoming increasingly important to understanding how
glioblastoma (GBM) tumor cells diffusely invade the brain. Yet, little is known of the …

Extracellular vesicle-mediated communication between the glioblastoma and its microenvironment

ER Matarredona, AM Pastor - Cells, 2019 - mdpi.com
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple
ways of communication with the tumor microenvironment in order to tune it for their own …

Tumor-derived extracellular vesicles regulate cancer progression in the tumor microenvironment

Q Bao, Q Huang, Y Chen, Q Wang, R Sang… - Frontiers in molecular …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are nanosized particles released by numerous kinds of cells,
which are now increasingly considered as essential vehicles of cell-to-cell communication …

Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease

DM Mallawaaratchy, S Hallal, B Russell, L Ly… - Journal of neuro …, 2017 - Springer
Extracellular vesicles (EVs) play key roles in glioblastoma (GBM) biology and represent
novel sources of biomarkers that are detectable in the peripheral circulation. Despite this …

Oncogenic extracellular vesicles in brain tumor progression

E D'Asti, D Garnier, TH Lee, L Montermini… - Frontiers in …, 2012 - frontiersin.org
The brain is a frequent site of neoplastic growth, including both primary and metastatic
tumors. The clinical intractability of many brain tumors and their distinct biology are implicitly …