Background Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in
maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti …

Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease
(AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness …

Purpose.: Both Th17 and Th1 cells contribute to experimental autoimmune uveoretinitis
(EAU). Interleukin-6 (IL-6) blockade inhibits Th17 differentiation in EAU and potently …

The aim of this study is to explore the dynamic changes in IL-17-expressing T cells
(Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU …

Retinitis pigmentosa (RP) comprises a group of incurable inherited retinal degenerations.
Targeting common processes, instead of mutation‐specific treatment, has proven to be an …

Background Age-related macular degeneration is the leading cause of visual deficiency in
older adults worldwide. Melatonin (MT) can potentially reduce retinal deterioration …

Abstract Background CD4+ T helper 17 (Th17) cells play a contributory role in uveitis and
other autoimmune disorders. However, less is understood about the contribution of …

Purpose To investigate the role of T-cell-mediated immune response in a monophasic
experimental autoimmune uveitis (EAU). Methods A monophasic EAU was induced in Lewis …

Abstract IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified
inflammatogenic cell population, which is critically involved in some inflammatory diseases …

Autoimmune uveitis, a group of potentially blinding intraocular inflammatory diseases,
remains a therapeutic challenge for ophthalmologists. Butyrates, which belong to the short …