New concepts in DNA methylation
A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
Rethinking how DNA methylation patterns are maintained
DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …
during the division of somatic cells. A long-established model for the maintenance of these …
Establishment and maintenance of DNA methylation patterns in mammals
T Chen, E Li - DNA Methylation: Basic Mechanisms, 2006 - Springer
In mammals, CpG methylation patterns are established and maintained during development
by the Dnmt1 and Dnmt3 families of DNA methyltransferases. These enzymes share …
by the Dnmt1 and Dnmt3 families of DNA methyltransferases. These enzymes share …
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
R Goyal, R Reinhardt, A Jeltsch - Nucleic acids research, 2006 - academic.oup.com
Abstract DNA methyltransferase 1 (Dnmt1) has a central role in copying the pattern of DNA
methylation after replication which is one manifestation of epigenetic inheritance. With …
methylation after replication which is one manifestation of epigenetic inheritance. With …
[HTML][HTML] Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase
G Vilkaitis, I Suetake, S Klimasauskas… - Journal of Biological …, 2005 - ASBMB
DNA methyltransferase Dnmt1 ensures clonal transmission of lineage-specific DNA
methylation patterns in a mammalian genome during replication. Dnmt1 is targeted to …
methylation patterns in a mammalian genome during replication. Dnmt1 is targeted to …
Mammalian DNA methyltransferases: new discoveries and open questions
As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an …
M Fatemi, A Hermann, S Pradhan, A Jeltsch - Journal of molecular biology, 2001 - Elsevier
The mammalian DNA methyltransferase Dnmt1 is responsible for the maintenance of the
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …
[HTML][HTML] Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro
IG Lin, L Han, A Taghva, LE O'Brien… - Molecular and cellular …, 2002 - Taylor & Francis
CpG methylation is involved in a wide range of biological processes in vertebrates as well
as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to …
as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to …