The packaging of DNA into nucleosomes and the organisation into higher order structures of
chromatin limits the access of sequence specific DNA binding factors to DNA. In cells, DNA …

Positioned nucleosomes limit the access of proteins to DNA. However, the impact of
nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we …

DNA methylation is an epigenetic modification of the genome critical for numerous
processes, including transcriptional repression and maintenance of chromatin structure …

The enzyme responsible for maintenance methylation of CpG dinucleotides in vertebrates is
DNMT1. The presence of DNMT1 in DNA replication foci raises the issue of whether this …

Specific DNA methylation at CpG and non-CpG sites is essential for chromatin regulation.
The DNA methyltransferase DNMT3A interacts with target sites surrounded by variable DNA …

The major DNA methyltransferase, Dnmt1, associates with DNA replication sites in S phase
maintaining the methylation pattern in the newly synthesized strand. In view of the slow …

Using peptide arrays and binding to native histone proteins, we show that the ADD domain
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di-and …

DNA methylation in promoter regions represses gene expression and is copied over mitotic
divisions by Dnmt1. Dnmt1 activity is regulated by its replication foci targeting sequence …

Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …