Quercetin Downregulates Cyclooxygenase‐2 Expression and HIF‐1α/VEGF Signaling‐Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm

L Wang, H Wu, L Xiong, X Liu, N Yang… - BioMed Research …, 2020 - Wiley Online Library
Objective. Abdominal aortic aneurysm (AAA) development has been characterized by
increased expression of vascular endothelial growth factor (VEGF), which contributes to …

Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice

L Wang, B Wang, H Li, H Lu, F Qiu, L Xiong… - European Journal of …, 2012 - Elsevier
Inflammation has been implicated as a contributing factor in the development of abdominal
aortic aneurysms (AAA). Quercetin, a natural flavonoid with anti-inflammatory properties, is …

[HTML][HTML] Preventive effects of quercetin against the onset of atherosclerosis-related acute aortic syndromes in mice

M Kondo, Y Izawa-Ishizawa, M Goda… - International journal of …, 2020 - mdpi.com
Atherosclerosis-related acute aortic syndromes, such as aortic aneurysms or aortic
dissection are life-threatening diseases. Since they develop suddenly and progress rapidly …

[HTML][HTML] Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of …

L Wang, X Cheng, H Li, F Qiu… - Molecular …, 2014 - spandidos-publications.com
Oxidative stress is becoming increasingly linked to the pathogenesis of abdominal aortic
aneurysms (AAAs). The antioxidant activity of flavonoids has attracted attention for their …

Inhibitory effects of quercetin on angiogenesis in larval zebrafish and human umbilical vein endothelial cells

D Zhao, C Qin, X Fan, Y Li, B Gu - European journal of pharmacology, 2014 - Elsevier
Angiogenesis plays an essential role in many physiological and pathological processes.
Quercetin, a plant pigment and traditional Chinese medicinal herb, is an important flavonoid …

[HTML][HTML] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways

P Pratheeshkumar, A Budhraja, YO Son, X Wang… - 2012 - journals.plos.org
Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the
growing tumor to receive oxygen and nutrients. Cancer prevention using natural products …

Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential

W Tan, L Lin, M Li, YX Zhang, Y Tong, D Xiao… - European Journal of …, 2003 - Elsevier
Quercetin, a dietary-derived flavonoid, suppresses tumor growth in vitro and in vivo, and
inhibits the activity of tyrosine kinase. The effects of quercetin on the angiogenic process …

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation

X Li, Q Fang, X Tian, X Wang, Q Ao… - Molecular …, 2017 - spandidos-publications.com
Angiogenesis is an important process in the pathogenesis of aortic aneurysm. The aim of the
present study was to investigate the angiogenic balance and the expression of vascular …

Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway

LZ Liu, Y Jing, LL Jiang, XE Jiang, Y Jiang… - Biochemical and …, 2011 - Elsevier
Acacetin (5, 7-dihydroxy-4′-methoxyflavone) is a flavone compound, some of which have
anti-cancerous effects. Vascular endothelial growth factor (VEGF) plays an important role in …

Curcumin attenuates angiotensin II‐induced abdominal aortic aneurysm by inhibition of inflammatory response and ERK signaling pathways

QQ Hao, X Chen, XY Wang, B Dong… - Evidence‐Based …, 2014 - Wiley Online Library
Background and Objectives. Curcumin has long been used to treat age‐related diseases,
such as atherosclerosis and coronary heart disease. In this study, we explored the effects of …