The majority of mammalian gene promoters are encompassed within regions of the genome
called CpG islands that have an elevated level of non-methylated CpG dinucleotides …

Most mammalian gene promoters are embedded within genomic regions called CpG
islands, characterized by elevated levels of nonmethylated CpG dinucleotides. Here, we …

Background More than 50% of human genes initiate transcription from CpG dinucleotide-
rich regions referred to as CpG islands. These genes show differences in their patterns of …

CpG islands are stretches of DNA sequence that are enriched in the (CpG) n repeat and are
present in close association with all housekeeping genes as well as some tissue-specific …

Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …

Up to 70% of human genes are associated with regions of nonmethylated DNA called CpG
islands (S. Saxonov, P. Berg, and DL Brutlag, Proc. Natl. Acad. Sci. USA 103: 1412–1417 …

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides,. Most human gene promoters are …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

In higher eukaryotes, up to 70% of genes have high levels of nonmethylated
cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units …

The primary target for DNA methylation in mammalian genomes is cytosine in the
dinucleotide CpG. High densities of CpG dinucleotides are found in CpG islands, but …