DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Mammalian CpG islands are key epigenomic elements that were first characterized
experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG …

Two-thirds of gene promoters in mammals are associated with regions of non-methylated
DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation …

DNA methylation in the genome plays a fundamental role in the regulation of gene
expression and is widespread in the genome of eukaryotic species. For example, in higher …

The inheritance of acquired traits in mammals is a highly controversial topic in biology.
Recently, Takahashi et al.(Cell 186: 715–731, 2023) have reported that insertion of CpG …

GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines.
GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon …