Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological
impact. Materials & methods: Microarray DNA methylation data were analyzed and …

Background Accurate outcome prediction in neuroblastoma, which is necessary to enable
the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma …

The downregulation of specific genes through DNA hypermethylation is a major hallmark of
cancer, although the extent and genomic distribution of hypermethylation occurring within …

Neuroblastoma (NB) pathogenesis has been reported to be closely associated with
numerous genetic alterations. However, underlying DNA methylation patterns have not been …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. The presence of epigenetic lesions, like hypermethylation of known tumor …

Background Neuroblastoma is the most common malignancy in infancy, accounting for 15%
of childhood cancer deaths. Outcome for the high-risk disease remains poor. DNA …

Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM).
Our goals were to study differential methylation across the genome in gene promoters using …

Background In this study we aimed to quantify tumor suppressor gene (TSG) promoter
methylation densities levels in primary neuroblastoma tumors and cell lines. A subset of …

Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore,
this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total …