Background A feature of glioblastoma (GBM) is cellular and molecular heterogeneity, both
within and between tumors. This variability causes a risk for sampling bias and potential …

Gliomas are tumors of the central nervous system with a wide spectrum of different tumor
types. They range from pilocytic astrocytoma, with a generally good prognosis, to the …

Neuroblastoma is a childhood cancer in which many children still have poor outcomes,
emphasising the need to better understand its pathogenesis. Despite recent genome‐wide …

Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two
extreme disease courses, spontaneous regression and life-threatening progression. Here …

Background Epigenetic mechanisms such as DNA methylation and histone modifications
are important regulators of gene expression and are frequently involved in silencing tumor …

Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-
associated deaths for adults, but the leading cause in pediatric patients and young adults …

Glioblastoma is one of the first tumors where the biological changes accompanying a single
epigenetic modification, the methylation of the MGMT gene, were found to be of clinical …

We explored the associations of aberrant DNA methylation patterns in 12 candidate genes
with adult glioma subtype, patient survival, and gene expression of enhancer of zeste …

Background Gliomas are the most common type of primary brain tumor and one of many
cancers where males are diagnosed with greater frequency than females. However, little is …

Background Aberrant DNA methylation is a prominent feature of many cancers, and may be
especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic …