Structural variation heavily influences the molecular landscape of cancer, in part by
impacting DNA methylation-mediated transcriptional regulation. Here, using multi-omic …

Epigenetic alterations, including methylation, have been shown to be an important
mechanism of gene silencing in cancer. Ependymoma has been well characterized at the …

Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at
diagnosis and is associated with an excellent outcome due to its remarkable capacity to …

Epigenetic alterations are hallmarks of cancer and powerful biomarkers, whose clinical
utilization is made difficult by the absence of standardization and of common methods of …

The 2021 WHO Classification of Tumors of the Central Nervous System includes several
tumor types and subtypes for which the diagnosis is at least partially reliant on utilization of …

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in adults.
The existence of a small population of stem-like tumor cells that efficiently propagate tumors …

Background Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with
a highly variable clinical course, ranging from spontaneous regression to life-threatening …

DNA methylation is increasingly used for tumour classification and has expanded upon the>
100 currently known brain tumour entities. A correct diagnosis is the basis for suitable …

Object Although most meningiomas are benign, about 20% are atypical (Grade II or III) and
have increased mortality and morbidity. Identifying tumors with greater malignant potential …

Molecular classification has improved diagnosis and treatment for patients with malignant
gliomas. However, classification has relied on individual assays that are both costly and …