Medulloblastoma arises in the cerebellum and is the most common malignant brain tumour
of childhood, however its molecular basis is not well understood. To assess the role of …

Abstract Background Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains
understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the …

Candidate gene investigations have indicated a significant role for epigenetic events in the
pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. To …

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor in adults
and prognosis of most GBM patients is poor. However, a small percentage of patients show …

Aims Paediatric brain tumours are rare, and establishing a precise diagnosis can be
challenging. Analysis of DNA methylation profiles has been shown to be a reliable method …

The high level of methylguanine‑DNA methyltransferase (MGMT) in glioblastoma is
responsible for resistance to alkylating agents, such as temozolomide (TMZ). In …

Background Wilms tumor is the most common pediatric renal malignancy and there is a
clinical need for a molecular biomarker to assess treatment response and predict relapse …

Pheochromocytomas and paragangliomas (PPGLs) are rare and frequently heritable neural-
crest derived tumours arising from the adrenal medulla or extra-adrenal chromaffin cells …

Medulloblastoma (MB), the most common form of pediatric brain malignancy, has a low
frequency of oncogenic mutations but pronouncedly abnormal DNA methylation changes …

Existing microarray-based approaches for screening of DNA methylation are hampered by a
number of shortcomings, such as the introduction of bias by DNA copy-number imbalances …