A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution
Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …
hampering our understanding of cell-type-specific contributions to disease development. As …
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
DNA methylation contributes to natural human variation
DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …
phenotypes, but little is known about their contribution to natural human variation. To …
Pan-cancer patterns of DNA methylation
T Witte, C Plass, C Gerhauser - Genome medicine, 2014 - Springer
The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …
Distinct chromatin signatures of DNA hypomethylation in aging and cancer
Cancer is an aging‐associated disease, but the underlying molecular links between these
processes are still largely unknown. Gene promoters that become hypermethylated in aging …
processes are still largely unknown. Gene promoters that become hypermethylated in aging …
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …
regulation and disease, but little is known about the mechanisms underlying inter-individual …
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution
Y Zhang, C Rohde, S Tierling, TP Jurkowski… - PLoS …, 2009 - journals.plos.org
Differential DNA methylation is an essential epigenetic signal for gene regulation,
development, and disease processes. We mapped DNA methylation patterns of 190 gene …
development, and disease processes. We mapped DNA methylation patterns of 190 gene …
DNA methylation of the first exon is tightly linked to transcriptional silencing
F Brenet, M Moh, P Funk, E Feierstein, AJ Viale… - PloS one, 2011 - journals.plos.org
Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …
environmental factors, and are often abnormal in human disease yet the cellular …
DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker
J Tost - DNA methylation: Methods and protocols, 2009 - Springer
DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …
DNA-binding factors shape the mouse methylome at distal regulatory regions
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
the rules that govern methylation patterns remain largely elusive. To gain insights into this …