Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two
extreme disease courses, spontaneous regression and life-threatening progression. Here …

Background/Aims: CpG island (CGI) methylator phenotype (CIMP) is strongly associated
with poor prognosis in neuroblastomas (NBLs; hazard ratios 7–22). Methylation of …

The CpG island methylator phenotype (CIMP) was closely associated with poor overall
survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in …

Background: Neuroblastoma is the most common extracranial solid malignancy in infancy
and childhood, but the biological factors involved in its development and progression are …

The hypermethylation of CpG islands within gene promoter regions is an epigenetic
phenomenon that is often, but not always, associated with the transcriptional silencing of …

CpG island hypermethylation has been recognized as an alternative mechanism for tumor
suppressor gene inactivation. In this study, we performed methylation-specific PCR (MSP) to …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological
impact. Materials & methods: Microarray DNA methylation data were analyzed and …

Background Epigenetic mechanisms such as DNA methylation and histone modifications
are important regulators of gene expression and are frequently involved in silencing tumor …

Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …