Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes

P Mathur, S Guo - Neurobiology of disease, 2010 - Elsevier
Despite massive research efforts the exact pathogenesis and pathophysiology of addiction
and neuropsychiatric disorders such as anxiety, schizophrenia and autism remain largely …

[HTML][HTML] Toward developmental models of psychiatric disorders in zebrafish

WHJ Norton - Frontiers in neural circuits, 2013 - frontiersin.org
Psychiatric disorders are a diverse set of diseases that affect all aspects of mental function
including social interaction, thinking, feeling, and mood. Although psychiatric disorders …

Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish

JM McCammon, H Sive - Disease models & mechanisms, 2015 - journals.biologists.com
The treatment of psychiatric disorders presents three major challenges to the research and
clinical community: defining a genotype associated with a disorder, characterizing the …

Zebrafish as an emerging model for studying complex brain disorders

AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

[HTML][HTML] Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models

TE Müller, BD Fontana, KT Bertoncello… - Progress in Neuro …, 2020 - Elsevier
Drug abuse and brain disorders related to drug comsumption are public health problems
with harmful individual and social consequences. The identification of therapeutic targets …

[HTML][HTML] Zebrafish: a translational model system for studying neuropsychiatric disorders

MS Ijaz, EJ Hoffman - Journal of the American Academy of Child …, 2016 - ncbi.nlm.nih.gov
With the advent of next-generation sequencing technologies, there has been considerable
progress in our ability to identify genes that are strongly associated with …

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Current state of modeling human psychiatric disorders using zebrafish

FV Costa, TO Kolesnikova, DS Galstyan… - International Journal of …, 2023 - mdpi.com
Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet
biomedical problem. Since reliable clinical diagnoses are essential for the treatment of …

The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium

S Shams, J Rihel, JG Ortiz, R Gerlai - Neuroscience & Biobehavioral …, 2018 - Elsevier
The zebrafish represents an excellent compromise between system complexity and practical
simplicity, features that make it useful for modeling and mechanistic analysis of complex …

Developing zebrafish models of autism spectrum disorder (ASD)

AM Stewart, M Nguyen, K Wong, MK Poudel… - Progress in Neuro …, 2014 - Elsevier
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder with complex
symptoms and unclear, multi-factorial pathogenesis. Animal (rodent) models of ASD-like …