Abstract Objective: Hypoxia-inducible factor 1 (HIF-1) regulates the expression of
angiogenic growth factors. We analyzed the effect of intramuscular (im) delivery of AdCA5 …

Hypoxia inducible factor (HIF)-1 and HIF-2 are transcription factors that mediate the cellular
response to hypoxia. Although HIF-1 and HIF-2 share the same target genes, both proteins …

Background. Our previous study showed that interleukin‐22 (IL‐22) levels were increased in
patients with aortic dissection (AD). This study evaluated the effects of IL‐22 on …

Induction of diabetes can produce arterial wall hypoxia preceding the formation of vascular
lesions. We therefore determined whether a dynamic interplay exists between …

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …

Hypoxia-inducible factor-1α is regulated at the post-mRNA level. The hypoxia-inducible
factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin …

Hypoxia‐inducible factor (HIF)‐1α and‐2α are key regulators of the transcriptional response
to hypoxia and pivotal in mediating the consequences of many disease states. In the present …

The circulatory system distributes blood flow to each tissue and transports oxygen and
nutrients. Peripheral circulation is required to maintain the physiological function in each …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a
number of adaptive responses to low oxygen tension. They are composed of α-and β …

Expression and Correlation of Hypoxia-Inducible Factor-1α (HIF-1α) with Pulmonary Artery
Remodeling and Right Ventricular Hypertrophy in Experimental Pulmonary Embolism - PMC …