How epigenetic information is propagated during somatic cell divisions is still unclear but is
absolutely critical for preserving gene expression patterns and cellular identity. Here we …

Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …

DNA methylation mostly occurs within the context of CpG dinucleotides and is essential for
embryonic development and gene repression. It is generally accepted that DNA …

Positioned nucleosomes limit the access of proteins to DNA. However, the impact of
nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we …

Cytosine methylation of genomic DNA controls gene expression and maintains genome
stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is …

In mammals, DNA methylation is crucial for embryonic development and germ cell
differentiation. The DNA methylation patterns are created by de novo-type DNA …

The packaging of DNA into nucleosomes and the organisation into higher order structures of
chromatin limits the access of sequence specific DNA binding factors to DNA. In cells, DNA …

DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …

Epigenetic control of gene expression in animals and plants is often correlated with changes
in cytosine methylation at specific chromosomal loci. This leads to the irreversible promoter …

Inactive DNA methyltransferase (DNMT) 3B splice isoforms are associated with changes in
DNA methylation, yet the mechanisms by which they act remain largely unknown. Using …