Manipulating cell fate in the cochlea: a feasible therapy for hearing loss

M Fujioka, H Okano, ASB Edge - Trends in neurosciences, 2015 - cell.com
Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower
vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is …

[HTML][HTML] Hair Cell Regeneration: From Animals to Humans

SW Choi, JM Abitbol, AG Cheng - Clinical and Experimental …, 2024 - synapse.koreamed.org
Cochlear hair cells convert sound into electrical signals that are relayed via the spiral
ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage …

[HTML][HTML] Hair cell regeneration from inner ear progenitors in the mammalian cochlea

S Zhang, R Qiang, Y Dong, Y Zhang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because
these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC …

Development and regeneration of the inner ear: Cell cycle control and differentiation of sensory progenitors

T Kwan, PM White, N Segil - Annals of the New York Academy …, 2009 - Wiley Online Library
Loss of sensory hair cells is the leading cause of deafness in humans. The mammalian
cochlea cannot regenerate its complement of sensory hair cells. Thus at present, the only …

Hair cell regeneration

Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

Regeneration of hair cells from endogenous otic progenitors in the adult mammalian cochlea: Understanding its origins and future directions

N Smith-Cortinez, AK Tan, RJ Stokroos… - International Journal of …, 2023 - mdpi.com
Sensorineural hearing loss is caused by damage to sensory hair cells and/or spiral ganglion
neurons. In non-mammalian species, hair cell regeneration after damage is observed, even …

Concise review: regeneration in mammalian cochlea hair cells: help from supporting cells transdifferentiation

B Franco, B Malgrange - Stem Cells, 2017 - academic.oup.com
It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair
cells are lost following an injury, no recovery could occur. However, during the first postnatal …

The challenge of hair cell regeneration

AK Groves - Experimental Biology and Medicine, 2010 - journals.sagepub.com
Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …

Recent advancements in the regeneration of auditory hair cells and hearing restoration

R Mittal, D Nguyen, AP Patel, LH Debs… - Frontiers in molecular …, 2017 - frontiersin.org
Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …

A brief history of hair cell regeneration research and speculations on the future

EW Rubel, SA Furrer, JS Stone - Hearing research, 2013 - Elsevier
Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …