Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia

DC Ding, MH Chiang, HC Lai, CA Hsiung… - European Journal of …, 2009 - Elsevier
OBJECTIVE: Oncogenic human papillomavirus (HPV) is the cause of cervical cancer.
Hypermethylation of the CpG islands located at the long control region (LCR) of the HPV …

[HTML][HTML] DNA methylation changes in human papillomavirus-driven head and neck cancers

C Ekanayake Weeramange, KD Tang, S Vasani… - Cells, 2020 - mdpi.com
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other
cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also …

[HTML][HTML] High-throughput detection of human papillomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia

T Turan, M Kalantari, K Cuschieri, HA Cubie… - Virology, 2007 - Elsevier
The L1 gene of human papillomavirus-18 (HPV-18) is consistently hypermethylated in
cervical carcinomas, but frequently hypo-or unmethylated in exfoliated cells from …

[HTML][HTML] Effects of cellular differentiation, chromosomal integration and 5-aza-2′-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured …

M Kalantari, D Lee, IE Calleja-Macias, PF Lambert… - Virology, 2008 - Elsevier
Human papillomavirus-16 (HPV-16) genomes in cell culture and in situ are affected by
polymorphic methylation patterns, which can repress the viral transcription. In order to …

Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions

A Chaiwongkot, S Vinokurova… - … journal of cancer, 2013 - Wiley Online Library
Enhanced expression of the HPV 16 E6‐E7 oncogenes may trigger neoplastic
transformation of the squamous epithelial cells at the uterine cervix. The HPV E2 protein is a …

CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic …

V Badal, LSH Chuang, EHH Tan, S Badal… - Journal of …, 2003 - Am Soc Microbiol
Infection with genital human papillomaviruses (HPVs) is the primary cause of cervical
cancer. The infection is widespread, and little is known about the secondary factors …

[HTML][HTML] Methylated host cell gene promoters and human papillomavirus type 16 and 18 predicting cervical lesions and cancer

N Milutin Gašperov, I Sabol, P Planinić, G Grubišić… - PloS one, 2015 - journals.plos.org
Change in the host and/or human papillomavirus (HPV) DNA methylation profile is probably
one of the main factors responsible for the malignant progression of cervical lesions to …

[HTML][HTML] High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes

L Cicchini, RZ Blumhagen, JA Westrich, ME Myers… - Scientific reports, 2017 - nature.com
Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-
associated cancer. We have recently reported that HPV E7-dependent promoter …

Human papillomavirus DNA methylation as a biomarker for cervical precancer: consistency across 12 genotypes and potential impact on management of HPV-positive …

MA Clarke, A Gradissimo, M Schiffman, J Lam… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Human papillomavirus (HPV) DNA methylation testing is a promising
triage option for women testing HPV positive during cervical cancer screening. However, the …

Quantitative measurement of Human Papillomavirus type 16 L1/L2 DNA methylation correlates with cervical disease grade

D Bryant, A Tristram, T Liloglou, S Hibbitts… - Journal of Clinical …, 2014 - Elsevier
Abstract Background Persistent infection with Human Papillomavirus (HPV) type 16 causes
the majority of cervical cancers. Genital HPV infection is very common, but neoplastic …