CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences
A Thain, O Jenkins, AR Clarke, K Gaston - Journal of virology, 1996 - Am Soc Microbiol
CpG methylation of the human papillomavirus upstream regulatory region has previously
been shown to reduce virus promoter activity. Here, we demonstrate that methylation of the …
been shown to reduce virus promoter activity. Here, we demonstrate that methylation of the …
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C
X Chen, JX Loo, X Shi, W Xiong, Y Guo, H Ke, M Yang… - Cancer research, 2018 - AACR
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract
dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 …
dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 …
In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
GJ Nuovo, TW Plaia, SA Belinsky… - Proceedings of the …, 1999 - National Acad Sciences
We have developed a technique, methylation-specific PCR in situ hybridization (MSP-ISH),
which allows for the methylation status of specific DNA sequences to be visualized in …
which allows for the methylation status of specific DNA sequences to be visualized in …
[HTML][HTML] E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma …
L Li, C Xu, J Long, D Shen, W Zhou, Q Zhou, J Yang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract In SiHa and CaSki cells, E6 and E7-targeting shRNA specifically and effectively
knocked down human papillomavirus (HPV) 16 E6 and E7 at the transcriptional level …
knocked down human papillomavirus (HPV) 16 E6 and E7 at the transcriptional level …
[HTML][HTML] Human papillomaviruses in epigenetic regulations
J Durzynska, K Lesniewicz, E Poreba - Mutation Research/Reviews in …, 2017 - Elsevier
Abstract Human Papillomaviruses (HPVs) are double-stranded DNA viruses, that infect
epithelial cells and are etiologically involved in the development of human cancer. Today …
epithelial cells and are etiologically involved in the development of human cancer. Today …
[HTML][HTML] HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the …
In cervical squamous cell carcinomas, high-risk human papillomavirus (HRHPV) DNA is
usually integrated into host chromosomes. Multiple integration events are thought to be …
usually integrated into host chromosomes. Multiple integration events are thought to be …
[HTML][HTML] Epigenetic regulation of human papillomavirus transcription in the productive virus life cycle
Human papillomaviruses (HPV) are a large family of viruses which contain a circular, double-
stranded DNA genome of approximately 8000 base pairs. The viral DNA is chromatinized by …
stranded DNA genome of approximately 8000 base pairs. The viral DNA is chromatinized by …
Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer
GM Poage, EA Houseman, BC Christensen… - Clinical cancer …, 2011 - AACR
Purpose: The human epigenome is profoundly altered in cancers, with a characteristic loss
of methylation in repetitive regions and concomitant accumulation of gene promoter …
of methylation in repetitive regions and concomitant accumulation of gene promoter …
Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium
Human papillomavirus (HPV) infection is the world's most common sexually transmitted
infection and is responsible for most cases of cervical cancer. Previous studies of global …
infection and is responsible for most cases of cervical cancer. Previous studies of global …
[HTML][HTML] HPV infection leaves a DNA methylation signature in oropharyngeal cancer affecting both coding genes and transposable elements
Simple Summary The HPV oncoproteins E6 and E7 can modulate the expression and
activity of the maintenance DNA methyltransferase 1, suggesting that HPV carcinogenic …
activity of the maintenance DNA methyltransferase 1, suggesting that HPV carcinogenic …