In contrast to epilepsy in adolescents and adults, neonatal seizures and early onset epilepsy
poses unique challenges with significant repercussion for treatment choices. Most …

Medically refractory neonatal seizures represent a major therapeutic challenge in neonatal
intensive care units. Conventional antiepileptic drugs demonstrate limited efficacy. Previous …

Abstract Objective Antiseizure medications (ASMs) remain the mainstay of epilepsy
treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which …

Epilepsy is one of the most common neurological disorders of childhood, and antiepileptic
drugs represent the main component of its treatment. The current emphasis in epilepsy …

Certain epilepsy types occur more commonly or exclusively in children and adolescents.
Proper diagnosis of the specific seizure type and the etiology of the seizure is the …

Most children with new-onset epilepsy achieve seizure freedom with appropriate
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …

Epilepsy is a common neurological condition that affects approximately 1% of the general
population. In addition, about 10% of the population experiences a seizure sometime during …

Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical
diagnosis is not easy as seizures are usually subtle in neonates. In the majority of newborn …

Over the last two decades, there has been a rapid expansion in the number and types of
available antiepileptic drugs (AEDs), but there is increasing concern amongst parents and …

Clinical trials provide the evidence needed for rational use of medicines. The evolution of
drug trials follows largely the evolution of regulatory requirements. This article summarizes …