Cancer is a heterogeneous and tissue-specific disease. Thus, the tissue of origin reflects on
the natural history of the disease and dictates the therapeutic approach. It is suggested that …

Breast cancer has been considered to be a multifactorial disease with a wide array of well-
characterized gene mutations and chromosomal abnormalities. However, it is becoming …

Aberrant methylation of CpG islands (CGI) not only plays a role in gene silencing, but is also
a potential cancer biomarker. To identify more CGI aberrantly methylated in human breast …

Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

Breast cancer (BC) is the most frequently diagnosed tumor in women worldwide. Although
the combination of surgery and Taxol chemotherapy can achieve a certain therapeutic effect …

The aim of the present study was to investigate the promoter methylation status of TRIM9 in
breast cancer and to determine the presence of TRIM9-methylated circulating tumor DNA …

DNA methylation, a DNA modification by adding methyl group to cytosine, has an important
role in the regulation of gene expression. DNA methylation is known to be associated with …

Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …

Recent data have revealed that epigenetic alterations, including DNA methylation and
chromatin structure changes, are among the earliest molecular abnormalities to occur during …