The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A
previous study that utilized zebrafish embryos provided a potent mechanism for active …

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms
and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5 …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

Cytosine methylation is an epigenetic and regulatory mark that functions in part through
recruitment of chromatin remodeling complexes containing methyl-CpG binding domain …

DNA methylation is a conserved epigenetic mark that plays important roles in plant and
vertebrate development, genome stability, and gene regulation. Canonical Methyl-CpG …

DNA methylation is crucial for normal development and cellular differentiation in many large-
genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently …

The methyl-CpG binding domain protein MBD3 has been shown to be essential for
embryonic development and differentiation, and to act by suppressing gene expression …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …

Complex biological processes are regulated by both genetic and epigenetic programs. One
class of epigenetic modifications is methylation. Evolutionarily conserved methyl-CpG …